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Treatment interruption

Treatments may be interrupted due to adverse drug events or poor patient compliance. Evidences are lacking on the management of treatment interruption. Expert opinions suggest:

For treatment with Antimonials:

-        Less than five days interruption do not need compensation

-        Interruptions from 5-10 days, need full course with compensation of the missed days

-        Interruptions for more than ten days should be managed with re-initiation as new with full course.

For treatment with liposomal form of amphotericin B, interruption is tolerable as it has long half-life.

Guidelines for diagnosis, treatment and prevention of leishmaniasis in Ethiopia, 2nd Ed. June 2013
WHO, control of the leishmaniasis, WHO technical report series 949, March 2010
Diro E et al, Clinical aspects of pediatric visceral leishmaniasis in North-west Ethiopia, TMIH, 2014
Mengesha B et al. Prevalence of malnutrition and associated risk factors among adult visceral leishmaniasis patients in Northwest Ethiopia: a cross sectional study. BMC research notes, 2014, 7:75.