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Treatment regimens

Treatment Regimens

Current WHO recommended treatment regimens in East Africa, in order of choice:

-        Pentavalent antimonials 20mg Sb5+/Kg IM or IV Plus Paromomycin 15mg/Kg (11mg base) IM for 17 days – efficacy 93%

-        Pentavalent antimonials 20mg Sb5+/Kg/day IM or IV for 30 days

-        Liposomal amphotericin B 3-5mg/kg/day IV infusion over 6-10days upto a total of 30mg/kg dose

-        Amphotericin B deoxycholate 0.75-1mg/kg/day infusion daily or alternate days 15-20 doses

-        Miltefosine 50mg BID PO for 28 days